Depot-specific adaption of adipose tissue for different exercise approaches in high-fat diet/streptozocin-induced diabetic mice

Background: Adipose tissue pathology plays a crucial role in the pathogenesis of type 2 diabetes mellitus. Understanding impact exercise training on adipose adaptation is paramount importance enhancing metabolic health. In this study, we aimed to investigate effects various modalities three distinct depots, namely, interscapular brown (iBAT), subcutaneous white (sWAT), and epididymal (eWAT), murine model diabetes. Methods: Male C57BL/6J mice received 12-week high-fat diet single injection streptozotocin, followed by an 8-week intervention. The intervention included swimming, resistance training, aerobic exercise, high-intensity interval (HIIT). Results: We found that reduced body weight fat percentage, diminished adipocyte size increased expression mitochondria-related genes (PGC1, COX4, COX8B) depots. inflammatory status include reduction crown-like structures factors, mainly eWAT. Besides, only induces browning sWAT, which may be related sympathetic marker tyrosine hydroxylase. Among four forms HIIT was most effective reducing increasing muscle mass eWAT size. oxidative phosphorylation thermogenesis-related sWAT highest group. Conclusion: When targeting improve diabetes, offer superior benefits thus represents more advantageous choice.